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Contraindications. Before taking sorafenib, tell your doctor or pharmacist if you are allergic to it. You should not use Nexavar if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane). Do not use Nexavar if you have kidney or liver problems other than cancer; lung cancer; a bleeding or blood clotting disorder such as hemophilia; high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain; a personal or family history of Long QT syndrome; a history of stroke or heart attack.
Drug interactions. The medications that may interact with Nexavar are dexamethasone, neomycin, St. John's wort, a blood thinner such as Warfarin, Coumadin, seizure medication such as carbamazepine, fosphenytoin, phenobarbital, phenytoin or tuberculosis medicine such as rifabutin, rifampin.

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